Welcome to the International Society of Applied Neuroimaging website!

As President of ISAN, it has been my pleasure and honor to spearhead our research and education efforts since the fledgling launch of this Society. This Society brings together a diverse international group of clinicians and scientists who share a common vision – that neuroimaging has real-world, clinical application today, not in some ephemeral future.

Our goals include:

  1. Education about functional neuroimaging, particularly single-photon emission computed tomography (SPECT) 
  2. Research on applications of SPECT which we collectively identify based on our real-world clinical experience
  3. Assisting clinicians in incorporating SPECT and other functional neuroimaging into their clinical practices
  4. Integrating Neurology, neurophysiology, neuroimaging, and Psychiatry into an integrated brain-based view of brain disease and brain health
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SPECT Brain Imaging  The Great Controversy

SPECT Brain Imaging The Great Controversy

Blood flow has long considered an accurate measure of brain function. The three principal Imaging technologies for measuring blood flow include Positron Emission Tomography (PET) scanning, Single Photon Emission Computerized Tomography (SPECT) scanning (both nuclear medicine techniques) and more recently functional…

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When Clinical Assessment Isn’t Enough

When Clinical Assessment Isn’t Enough

The ability to generate accurate maps of brain metabolism, while scientifically interesting, is of little use to medicine unless those maps help answer clinical questions which cannot be otherwise answered. One important test-case is mood disorders. Major Depressive Disorder, also called unipolar depression, treated with antidepressants, and Bipolar Disorder, treated with mood stabilizers, both feature depressive episodes which are clinically identical. Furthermore, many cases of bipolar disorder begin with a depressive episode, particularly in females.

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Neuroimaging

Neuroimaging, in its most basic definition, refers to a set of techniques used to create pictures of the structure and functionality of the brain. Functional neuroimaging refers to visualizing functional processes in the brain that derive from the electrochemical activity of the brain’s neurons, synaptic transmission, and the metabolism that supports these processes.

Neurons can control the localized flow of blood by molecular signaling mediated by the neurotransmitter glutamate via the surrounding astrocytes. When blood enters the brain, it doesn’t course indiscriminately through the organ’s vessels; instead it is selectively channeled to specific regions in a need-based fashion. As a result perfusion to cortical regions and even areas as small as a single cortical column adjusts moment to moment to meet the constantly changing metabolic demands of the neurons.

Areas of the brain become more active during a task, requiring more energy, which is provided by an almost instantaneous change in local perfusion to provide the necessary glucose. Functional neuroimaging techniques, such as functional magnetic resonance imaging (fMRI) and SPECT, take advantage of this intimate association between neuronal activity, metabolic activity, and local perfusion.

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The International Society of Applied Neuroimaging is committed to the education of the medical field on these and other issues involved in functional neuroimaging.

The Society is committed to enhancing the research and knowledge base upon which SPECT neuroimaging and other functional neuroimaging can be applied in the clinical setting.

We look forward to addressing your needs. Enhancing the research and knowledge base upon which functional neuroimaging can be clinically applied.

About The Authors

Theodore Henderson MD, PhD

Theodore Henderson MD, PhD

co-founder of Neuro-Luminance and director of The Synaptic Space. He has extensive training and experience to the practice of Psychiatry and brain sciences.

John Michael Uszler, M.D.

John Michael Uszler, M.D.

co-founder of Neuro-Luminance.com, Medical Director of drspectscan.com, is Assistant Clinical Professor of Molecular and Medical Pharmacology at UCLA, and Medical Director of the Nuclear Medicine Department at St Johns Health Center in Santa Monica, CA.

Dr. Muriel J. van Lierop

Dr. Muriel J. van Lierop

Dr. Muriel J. van Lierop graduated in medicine from London University, London, England with an MBBS. After practising primarily in rehabilitation medicine in Toronto, Ontario she started to focus her practice in 1992 on psychotherapy, training in several modalities. Presently is also working with Drs. John Thornton and Mary McLean, Psychiatrists, arranging for patients to have SPECT Scans of the brain at Mount Sinai Hospital in Toronto and using these to aid in treatment and management.